GENERAL CATALOGUE
USP28-IN-3
HY-149229 · 1 mg
MedChemExpress · Cat: HY-149229
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medchemexpress.com/usp28-in-3.htmlCatalog No: HY-149229
CAS No: 2931509-14-5
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
USP28-IN-3 is a USP28 inhibitor IC50=0.1 ?M with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib HY-10331 .