GENERAL CATALOGUE
UB-221
HY-P991592 · 1 mg
MedChemExpress · Cat: HY-P991592
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medchemexpress.com/ub-221.htmlCatalog No: HY-P991592
CAS No: 2755114-30-6
Pack Size: 1 mg
Brand: MedChemExpress
Description
UB-221 is a humanized IgG1 monoclonal antibody inhibitor targeting IgE. UB-221 significantly decreases IgE synthesis by stabilization of membrane-bound CD23 on B lymphocytes and inhibits Fc?RI-mediated basophil activation and degranulation. UB-221 reduces IgE level in cynomolgus macaques and human IgE ?, ? -transgenic hIGHE-knockin mice. UB-221 can be used for asthma and chronic spontaneous urticaria CSU research.