GENERAL CATALOGUE
TYD-68
HY-173357 · 5 mg
MedChemExpress · Cat: HY-173357
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Manufacturer product page
medchemexpress.com/tyd-68.htmlCatalog No: HY-173357
Category: Epigenetics
Pack Size: 5 mg
Brand: MedChemExpress
Description
TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-?-induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2-dependent signaling pathways. TYD-68 can be used in the study of psoriasis. Pink: Target protein ligand HY-173359 ; Black: Linker HY-W007732B ; Blue: E3 ligase ligand HY-14658 ; E3 ligase ligand + Linker HY-173358 .
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