Tryptamine

Description

Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist EC50=1-3 mM and an endogenous ligand of the aryl hydrocarbon receptor AHR Kd=10-50 nM . Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors GPCRs and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models.