Trovirdine hydrochloride

Description

Trovirdine hydrochloride, a phenethylthiazolylthiourea PETT derivative, is an HIV reverse transcriptase RT non-nucleoside inhibitor NNI . A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochlorides pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells.