GENERAL CATALOGUE
TK-129
HY-151483 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-151483
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medchemexpress.com/tk-129.html
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Catalog No: HY-151483
CAS No: 3031476-73-7
Category: Epigenetics
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor with high affinity; IC50=44 nM . TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease.
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