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ab282420 · 5 mg
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Catalog No: ab282420
Category: Biochemicals
Pack Size: 5 mg
Brand: abcam
Description
MW 566.1 Da, Purity 97 %. A potent IC50 = 15.6nM at 20 minutes and selective inhibitor that combines allosteric covalent binding and ATP-site binding to irreversibly inhibit cyclin-dependent kinase 7 CDK7 . It demonstrates strong anti-proliferative effects across types of cancers and cell lines by disrupting transcription of several proteins and decreasing binding of STAT3 chromatin and target gene expression of genes such as MYC and PIM1.
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