GENERAL CATALOGUE
Thalidomide 5-fluoride
HY-W087383 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-W087383
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Catalog No: HY-W087383
CAS No: 835616-61-0
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands e.g. IRAK4 through a linker to form PROTAC molecules e.g. PROTAC IRAK4 degrader-1 . PROTAC IRAK4 degrader-1 caused 20 %, 20-50 %, and >50 % IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 ?M, respectively.
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