GENERAL CATALOGUE
SR 142948
HY-107664 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-107664
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medchemexpress.com/sr-142948.htmlCatalog No: HY-107664
CAS No: 184162-64-9
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SR 142948 is an orally active and selective non-peptide neurotensin receptor NT antagonist with IC50s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders.
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