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SP600125, JNK inhibitor
ab120065 · 10 mg
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Catalog No: ab120065
Category: Biochemicals
Pack Size: 10 mg
Brand: abcam
Description
MW 220.23 Da, Purity >99 %. Potent and selective JNK1, -2, and -3 inhibitor IC50 = 0.11 muM . SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNgamma and TNFalpha. Neuroprotective in vivo.
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