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SN 38, DNA topoisomerase I inhibitor
ab141108 · 10 mg
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Catalog No: ab141108
Category: Biochemicals
Pack Size: 10 mg
Brand: abcam
Description
MW 392.4 Da, Purity >99 %. Active metabolite of CPT-11 Irinotecan ab141107 . Inhibits DNA topoisomerase I IC50 values are 0.74 and 1.9 muM in P388 and Ehrlich cells respectively and DNA and RNA synthesis IC50 values are 77 nM and 1.3 muM respectively . Shows potent antitumor activity, causes S- and G2 cell cycle arrest and induces apoptosis. Active in vivo.
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