GENERAL CATALOGUE
SirReal2
HY-100591 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-100591
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medchemexpress.com/sirreal2.htmlCatalog No: HY-100591
CAS No: 709002-46-0
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140?nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 HY-16585 suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration.
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