GENERAL CATALOGUE
S2116
HY-136522 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-136522
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Catalog No: HY-136522
CAS No: 2262489-89-2
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
S2116, a N-alkylated tranylcypromine TCP derivative, is a potent lysine-specific demethylase 1 LSD1 inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia T-ALL cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T-ALL cells in xenotransplanted mice.
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