RSS0680

Description

RSS0680 is a small noncoding RNA sRNA targeting the mRNA ribosome binding site RBS and a PROTAC with protein kinase degradation activity Pink: FLT3-IN-17 HY-148070 ; Black: Linker HY-W041970 ; Blue: E3 ligase Ligand HY-112078 . RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno aSD sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the hosts resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in ?-proteobacteria 1 2 .