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Rottlerin
GENERAL CATALOGUE

Rottlerin

HY-18980 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-18980

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Manufacturer product page

medchemexpress.com/Rottlerin.html
Catalog No: HY-18980
CAS No: 82-08-6
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKC? of 3-6 ?M, PKC?,?,? of 30-42 ?M, PKC?,?,? of 80-100 ?M. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation. Rottlerin inhibits HIV-1 integration and Rabies virus RABV infection.

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