RGMa, His & Avi, Human

Description

Repulsive guidance molecule RGM is a glycosylphosphatidylinositol GPI -anchored glycoprotein that has diverse functions in the developing and pathological central nervous system CNS . The binding of RGM to its receptor neogenin regulates axon guidance, neuronal differentiation, and survival during the development of the CNS. RGMa induces T cell activation in experimental autoimmune encephalomyelitis EAE , which is the animal model of multiple sclerosis MS . RGM is expressed in pathogenic Th17 cells and induces neurodegeneration by binding to neogenin.