Recombinant Mouse SCF (C-6His)

Description

EnkiLife provides the Recombinant Mouse SCF (C-6His) protein,aslo know as FPH2,KIT ligand,Kitl,KITLG,KL-1,Mast cell growth factor,MGF,MGFSHEP7,SCF,SCFStem cell factor,SFc-Kit ligand,SLF,steel factor, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Kit Ligand is produced by our Mammalian expression system and the target gene encoding Lys26-Ala189 is expressed with a 6His tag at the C-terminus.Accession:P20826. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:19.3 KDa. Background:SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.