(rac)-ZK-304709

Description

rac -ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases CDKs , vascular endothelial growth factor receptor kinases VEGF-RTKs , and platelet-derived growth factor receptor kinase ? PDGF-RTK? . rac -ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor NET cells. rac -ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1?. rac -ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET.