GENERAL CATALOGUE
PS10
HY-121744 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-121744
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Catalog No: HY-121744
CAS No: 1564265-82-2
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 ?M, 0.76 ?M, 2.1 ?M and 21.3 ?M for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 Kd= 239 nM than for Hsp90 Kd= 47 ?M . PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy.PDK: pyruvate dehydrogenase kinase
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