Phosphofructokinase 1

Description

Phosphofructokinase 1 PFK1 is a major regulatory enzyme targeting glycolytic pathway. Phosphofructokinase 1 catalyzes the phosphorylation of fructose-6-phosphate F6P to fructose-1,6-bisphosphate F1,6BP to regulate glycolytic flux. Phosphofructokinase 1 is promising for research of cancer metabolic reprogramming e.g., hypoxia adaptation, oxidative stress resistance and metabolic syndromes.