Pevonedistat (Standard)

Description

Pevonedistat Standard is the analytical standard of Pevonedistat. This product is intended for research and analytical applications. Pevonedistat MLN4924 is a potent and selective NEDD8-activating enzyme NAE inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice.