GENERAL CATALOGUE
Pactimibe
HY-100401 · 5 mg
MedChemExpress · Cat: HY-100401
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Catalog No: HY-100401
CAS No: 189198-30-9
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
Pactimibe CS-505 free base is a dual ACAT1/2 inhibitor with IC50s of 4.9 ?M and 3.0 ?M, respectively. Pactimibe CS-505 free base inhibits ACAT with IC50s of 2.0 ?M, 2.7 ?M, 4.7 ?M in the liver, macrophages and THP-1 cells, respectively. Pactimibe CS-505 free base noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 ?M. Moreover, Pactimibe CS-505 free base obviously inhibits cholesteryl ester formation with an IC50 of 6.7 ?M. Pactimibe CS-505 free base possesses anti-atherosclerotic potential with lowering plasma cholesterol activity.
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