p53RFP Rabbit Polyclonal Antibody

Description

EnkiLife offers the p53RFP Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for WB,ELISA application. Alternative Names of Immunogen: RNF144B; IBRDC2; P53RFP; E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,ELISA 1:20000-1:40000 Background: caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family. domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. function:E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. pathway:Protein modification; protein ubiquitination. PTM:Auto-ubiquitinated. similarity:Belongs to the RBR family. RNF144 subfamily. similarity:Contains 1 IBR-type zinc finger. similarity:Contains 2 RING-type zinc fingers. subunit:Interacts with UBE2L3, UBE2L6 and LCMT2. tissue specificity:Broadly expressed, with lowest levels in brain, spleen and thymus.