GENERAL CATALOGUE
P2Y14R antagonist 1
HY-161727 · 5 mg
MedChemExpress · Cat: HY-161727
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medchemexpress.com/p2y14r-antagonist-1.htmlCatalog No: HY-161727
CAS No: 2728291-29-8
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
P2Y14R antagonist 1 compound I-17 is a selective P2Y14R antagonist with an IC50 of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 NLRP3 /gasdermin D GSDMD signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis.
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