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(-)-Nutlin-3, p53-MDM2 binding inhibitor
ab144428 · 1 mg
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Catalog No: ab144428
Category: Biochemicals
Pack Size: 1 mg
Brand: abcam
Description
MW 581.5 Da, Purity >98 %. Potent p53-MDM2 binding inhibitor IC50 = 90 nM . Enantiomer of + -Nutlin-3 ab144426 . Shows antiproliferative effects IC50 values are 2.2 and 1.3 muM for human skin and murine fibroblasts respectively . Shows antitumor effects in vivo. Orally active.
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