NDR2 Rabbit Polyclonal Antibody

Description

EnkiLife offers the NDR2 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: STK38L; KIAA0965; NDR2; Serine/threonine-protein kinase 38-like; NDR2 protein kinase; Nuclear Dbf2-related kinase 2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:50-1:300,ICC/IF 1:50-1:200,ELISA 1:10000-1:20000 Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L. function:Involved in the regulation of structural processes in differentiating and mature neuronal cells. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. similarity:Contains 1 AGC-kinase C-terminal domain. similarity:Contains 1 protein kinase domain. subcellular location:Associated with the actin cytoskeleton. subunit:Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2. tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.