NARF Rabbit Polyclonal Antibody

Description

EnkiLife offers the NARF Rabbit Polyclonal Antibody. This antibody reacts with Human,Rat,Mouse species and is suitable for WB,IHC,ELISA application. Alternative Names of Immunogen: NARF; Nuclear prelamin A recognition factor; Iron-only hydrogenase-like protein 2; IOP2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:50-1:300,ELISA 1:2000-1:20000 Background: Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. ItPTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the NARF family.,subunit:Interacts with LMNA and binds to the farnesylated C-terminal domain.,tissue specificity:Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.,