GENERAL CATALOGUE
Narazaciclib
HY-12624 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-12624
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medchemexpress.com/narazaciclib.htmlCatalog No: HY-12624
CAS No: 1357470-29-1
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Narazaciclib ON123300 , a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 IC50=3.9 nM , Ark5 IC50=5 nM , PDGFR? IC50=26 nM , FGFR1 IC50=26 nM , RET IC50=9.2 nM , and FYN IC50=11 nM . Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors. Narazaciclib inhibits CDK6 with an IC50 of 9.82 nM.