GENERAL CATALOGUE
MS453
HY-116255 · 50 mg
MedChemExpress · Cat: HY-116255
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medchemexpress.com/ms453.htmlCatalog No: HY-116255
CAS No: 2059892-29-2
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
MS453 is a potent and highly selective SETD8 inhibitor with an IC50 value of 804 nM. MS453 specifically modifies a cysteine residue close to the inhibitor binding site. MS453 is selective for 28 other methyltransferases. The crystal structure of MS453 reveals its binding mode to SETD8, providing an atomic-level view for the development of high-quality chemical probes for SETD8.