GENERAL CATALOGUE
MOMA-341
HY-175750 · 50 mg
MedChemExpress · Cat: HY-175750
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medchemexpress.com/moma-341.htmlCatalog No: HY-175750
CAS No: 3078276-74-8
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
MOMA-341 is a selective Werner RecQ like helicase WRN inhibitor. MOMA-341 binds to WRN at cysteine 727 through an allosteric and ATP-competitive binding mechanism. MOMA-341 induces DNA damage, cell death, and tumor regressions in mismatch-repair deficient dMMR /microsatellite instability high MSI-H mice model. MOMA-341 has antitumor activity, promising for advanced and metastatic solid tumors research.