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MM-102 (HMTase Inhibitor IX)
ab287022 · 5 mg
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Catalog No: ab287022
Category: Biochemicals
Pack Size: 5 mg
Brand: abcam
Description
MW 669.8 Da, Purity >98 %. MM-102 HMTase Inhibitor IX is a potent WDR5/MLL interaction inhibitor IC50 = 2.4 nM . It has been shown to block MLL1 methyltransferase activity, reducing the expression of HoxA9 and Meis-1 genes, which are both critical MLL1 target genes in MLL1 fusion protein-mediated leukemogenesis. WD-repeat protein 5 WDR5 is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.
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