mGlu Agonists Kit

Description

A collection of 7 agonists and modulators for a range of mGlu receptor subtypes. Products are freeze-dried as an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM, respectively. The kit contains S -3,5-DHPG ab120007 , R,S -CHPG sodium salt ab120221 , LY 379268 ab120196 , L-AP4 ab120002 , VU0155041 sodium salt ab120248 , AMN082 dihydrochloride ab120011 and S -3,4-DCPG ab120006 . Please note that AMN082 dihydrochloride ab120011 is only soluble to 5 mM in water. Receptor Description. mGlu1,5 S -3,5-DHPG: Selective group I mGlu agonist. Suggested Solvent: Water mGlu5 R,S -CHPG sodium salt: Water soluble form of R,S -CHPG ab120039 , a selective mGlu5 agonist. Suggested Solvent: Water mGlu2,3 LY379268: Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays > 80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain. Suggested Solvent: Water mGlu4,6,7,8 group III L-AP4: Selective group III mGlu receptor agonist. Suggested Solvent: Water mGlu4 VU0155041 sodium salt: Water soluble, positive allosteric selective modulator at mGluR4 EC50 values are 798 nM and 693 nM at human and rat mGluR4 receptors, respectively . It has advantages over PHCCC ab120043 as it is water soluble and more potent. Active in behavioural models of Parkinsons Disease. Suggested Solvent: Water mGlu7 AMN082 dihydrochloride: Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding EC50 = 64-290 nM in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4, 5, 6 and 8 and ionotropic receptors up to 10 muM . Elevates plasma stress hormones in vivo. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones. Suggested Solvent: Water 5 mM / DMSO 10 mM mGlu8 S -3,4-DCPG: Potent, selective mGlu8a agonist EC50 = 31 nM . Displays > 100-fold selectivity over mGlu7. Systemically active in vivo. Suggested Solvent: Water Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. KIT