GENERAL CATALOGUE
MG-277
HY-130122 · 1 mg
MedChemExpress · Cat: HY-130122
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medchemexpress.com/mg-277.htmlCatalog No: HY-130122
CAS No: 2411085-89-5
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity.
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