MAP2K3 Mouse Monoclonal Antibody

Description

EnkiLife offers the MAP2K3 Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for IHC,ICC,ELISA,FC application. Alternative Names of Immunogen: MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:200-1:1000,ICC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. Research Area: TGF-beta signaling pathway,MAPK signaling pathway,Jak-STAT signaling pathway