LRBA Rabbit Polyclonal Antibody

Description

EnkiLife offers the LRBA Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for IHC,ICC/IF application. . The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:50-1:300,ICC/IF 1:50-1:200 Background: The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],caution:Was originally (PubMed:1505956) said to be similar to yeast CDC4, but that similarity is very limited.,induction:By lipopolysaccharide (LPS).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 BEACH domain.,similarity:Contains 6 WD repeats.,