GENERAL CATALOGUE
Losartan Carboxylic Acid
HY-12765 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-12765
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Catalog No: HY-12765
CAS No: 124750-92-1
Category: GPCR G Protein
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Losartan Carboxylic Acid E-3174 , an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 AT1 antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells VSMC . Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.