GENERAL CATALOGUE
Lomibuvir
HY-75800 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-75800
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Manufacturer product page
medchemexpress.com/vx-222.htmlCatalog No: HY-75800
CAS No: 1026785-55-6
Category: Anti-infection
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Lomibuvir VX-222 , a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase RdRp with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.