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Linsitinib (OSI-906)
ab273391 · 10 mg
AB
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Catalog No: ab273391
Category: Biochemicals
Pack Size: 10 mg
Brand: abcam
Description
MW 421.5 Da, Purity 98 %. Potent and selective dual IGF-1R IC50 = 35 nM in cell-free assay and Insulin Receptor IC50 = 75 nM in cell-free assay kinase inhibitor. Inactive towards Abl, ALK, BTK, EGFR, FGFR1/2 and PKA. Displayed <50 % inhibition at 1 muM against a panel of 88 kinases. Blocks IGF-1R autophosphorylation and downstream activation of Akt, ERK1/2 and S6 kinase. Blocks tumor cell line proliferation. Blocks IGF-1R driven tumor xenograft growth.
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