Lenalidomide-d4

Description

Lenalidomide-d4 CC-5013-d4 is deuterium labeled Lenalidomide. Lenalidomide CC-5013 , a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide CC-5013 is a ligand of ubiquitin E3 ligase cereblon CRBN , and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide CC-5013 specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.