KMI169

Description

KMI169 is a potent and selective inhibitor targeting lysine methyl-transferase KMT9 IC50 = 0.05 ?M, Kd = 0.025 ?M . KMI169 functions as a bi-substrate inhibitor targeting the cofactor S-5AAasAasAa-adenosyl-L-methionine SAM and substrate binding pockets of KMT9. KMI169 can downregulate target genes involved in cell cycle regulation and impair proliferation of tumor cells by inhibiting KMT9. KMI169 is a valuable tool to probe cellular KMT9 functions and can be research for combating diseases including prostate, lung, colon, and invasive bladder cancer.