KD-Validated PRKAR2A Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated PRKAR2A Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha; PRKAR2; Protein Kinase, CAMP-Dependent, Regulatory Subunit Type II Alpha; CAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit; PKR2; Protein Kinase, CAMP-Dependent, Regulatory, Type II, Alpha; CAMP-Dependent Protein Kinase Regulatory Subunit RII Alpha; Protein Kinase A, RII-Alpha Subunit Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008] Research Area: Signal Transduction,Cancer,Metabolism