KD-Validated NAE1 Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated NAE1 Mouse Monoclonal Antibody. This antibody reacts with Human,Rat and is suitable for WB,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:400-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:NAE1; NEDD8 Activating Enzyme E1 Subunit 1; APP-BP1; APPBP1; Ula-1; Amyloid Beta Precursor Protein-Binding Protein 1, 59 KDa ; Amyloid Beta Precursor Protein Binding Protein 1, 59kDa; NEDD8-Activating Enzyme E1 Regulatory Subunit; Amyloid Protein-Binding Protein 1; Proto-Oncogene Protein 1; Amyloid Beta Precursor Protein-Binding Protein 1, 59kD; NEDD8-Activating Enzyme E1 Subunit; Protooncogene Protein 1; A-116A10.1; NEDFIH; HPP1 Background: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Research Area: Cancer