KD-Validated GALE Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated GALE Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2,500; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:GALE; UDP-Galactose-4-Epimerase; UDP-Glucose 4-Epimerase; SDR1E1; Short Chain Dehydrogenase/Reductase Family 1E, Member 1; UDP-N-Acetylgalactosamine 4-Epimerase; UDP-N-Acetylglucosamine 4-Epimerase; Galactose-4-Epimerase, UDP-; UDP-GalNAc 4-Epimerase; UDP-GlcNAc 4-Epimerase; Galactowaldenase; EC 5.1.3.2; Epididymis Secretory Sperm Binding Protein; UDP Galactose-4'-Epimerase; UDP-Galactose 4-Epimerase; EC 5.1.3.7; EC 5.1.3 47; THC13 Background: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and cognitive disability, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008] Research Area: Cancer