KD-Validated Core-Binding Factor Subunit Beta Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Core-Binding Factor Subunit Beta Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:CBFB; Core-Binding Factor Subunit Beta; PEBP2B; SL3/AKV Core-Binding Factor Beta Subunit; SL3-3 Enhancer Factor 1 Subunit Beta; Core-Binding Factor Beta Subunit; PEBP2-Beta; PEA2-Beta; CBF-Beta; Polyomavirus Enhancer Binding Protein 2, Beta Subunit; Polyomavirus Enhancer-Binding Protein 2 Beta Subunit; SL3-3 Enhancer Factor 1 Beta Subunit; Core-Binding Factor, Beta Subunit; CLCD2 Background: The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Research Area: Epigenetics and Nuclear Signaling