GENERAL CATALOGUE
K67
HY-111126 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-111126
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Catalog No: HY-111126
CAS No: 2046250-48-8
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
K67 is a selective the interaction between Keap1 and S349 phosphorylated p62 inhibitor, with an IC50 of 1.5 ?M. K67 has a weaker inhibitory effect on the interaction between Keap1 and Nrf2 IC50 is 6.2 ?M . K67 competitively binds to the binding site of Keap1 with p-p62, blocking the abnormal activation of the p62-dependent Nrf2 pathway. K67 inhibits tumor cell proliferation and enhances the sensitivity of hepatocellular carcinoma HCC to chemotherapeutic drugs by restoring Keap1-mediated ubiquitination and degradation of Nrf2.
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