GENERAL CATALOGUE
JH295
HY-116423 · 5 mg
MedChemExpress · Cat: HY-116423
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medchemexpress.com/jh295.htmlCatalog No: HY-116423
CAS No: 1311143-71-1
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
JH295 is a potent, irreversible and selective NIMA-related kinase 2 Nek2 inhibitor with an IC50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint. JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition CuAAc with molecules containing Azide groups.