GENERAL CATALOGUE
JH-131e-153
HY-149489 · 50 mg
MedChemExpress · Cat: HY-149489
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medchemexpress.com/jh-131e-153.htmlCatalog No: HY-149489
CAS No: 742104-91-2
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
JH-131e-153, a diacylglycerol DAG -lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590?R592A?W588A. The C1 domain of Munc13-1 and protein kinase C PKC are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKC?>Munc13-1>PKC?. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases.