iNOS/TopoI-IN-1

Description

iNOS/TopoI-IN-1 compound AuL9 is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 ?M and 6.3 ?M, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I TopoI Ki=2.72 ?M . In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB Ki=1.49 ?M .