Immortalized Mouse Leptin Receptor-deficient Macrophage Cells (DB-1)

Description

The Immortalized Mouse Leptin Receptor-deficient Macrophage Cells DB-1 are non-transformed cells derived from leptin-receptor LepR deficient mice which display some phenotypic and functional properties similar to primary macrophages. The cells are characterized as early differentiated macrophages since the high expression of MAC-2, and low expression of F4/80, Ly6G and Ly6C were observed; but CD11b expression was absent. It is recommended for use in studies involving the role of the leptin receptor, susceptibility to infections, innate immune functions, and obesity.