GENERAL CATALOGUE
HDGFRP2/PSIP1-IN-1
HY-W023758 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-W023758
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Catalog No: HY-W023758
CAS No: 166196-54-9
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
HDGFRP2/PSIP1-IN-1 compound BPP is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 HDGFRP2 and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma DIPG . HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 ?M and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 ?M; meanwhile, it has a Kd value of 14 ?M for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily.
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